Creating new treatments to prevent preterm birth using a special chip technology
Developing extracellular vesicle based therapeutics against pre-term birth through the use of maternal-fetal interface on a chip
['FUNDING_OTHER'] · TEXAS ENGINEERING EXPERIMENT STATION · NIH-11019674
This study is exploring new ways to help prevent preterm birth by looking at how cells from moms and babies interact, using a special model that mimics pregnancy, and it aims to find treatments that can reduce inflammation and improve outcomes for expectant parents.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | TEXAS ENGINEERING EXPERIMENT STATION (nih funded) |
| Locations | 1 site (COLLEGE STATION, UNITED STATES) |
| Trial ID | NIH-11019674 on ClinicalTrials.gov |
What this research studies
This research focuses on developing innovative therapies to prevent preterm birth by studying the interactions between maternal and fetal cells using a cutting-edge organ-on-chip model. The approach involves engineering tiny vesicles that can modulate immune responses, which are crucial for maintaining a healthy pregnancy. By mimicking the maternal-fetal interface, the research aims to identify effective treatments that can reduce inflammation and improve pregnancy outcomes. Patients may benefit from insights gained through this research, which could lead to new preventative strategies against preterm birth.
Who could benefit from this research
Good fit: Ideal candidates for this research are pregnant individuals at risk of preterm birth, particularly those with a history of premature deliveries or inflammatory conditions.
Not a fit: Patients who are not pregnant or those with pregnancies that are already considered high-risk due to other complications may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could significantly reduce the rates of preterm birth and improve neonatal health outcomes.
How similar studies have performed: While the use of organ-on-chip technology is relatively novel, preliminary studies have shown promise in similar approaches for understanding pregnancy-related complications.
Where this research is happening
COLLEGE STATION, UNITED STATES
- TEXAS ENGINEERING EXPERIMENT STATION — COLLEGE STATION, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: HAN, ARUM — TEXAS ENGINEERING EXPERIMENT STATION
- Study coordinator: HAN, ARUM
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.