Creating new treatments to help reduce appetite and manage blood sugar levels
Official title: Development of Anorexigenic and Glucoregulatory Chimeric Peptides
Funded at Seattle Children's Hospital · NIH-10913620 · Data updated 2026-11-12
This study is looking at a new type of treatment that uses special peptides to help control hunger and blood sugar levels, which could be great for people struggling with obesity, as it aims to reduce appetite and improve health without the usual side effects.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Seattle Children's Hospital NIH-funded |
| Lab location | 1 site (Seattle, United States) |
| Project start | September 1, 2023 |
| Project end | August 31, 2027 |
| Funding year | 2024 |
| Award (this year) | $644,494 |
| NIH project number | 5R01DK135125-02 |
| Project ID | NIH-10913620 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are adults aged 21 and older who are struggling with obesity or related metabolic disorders.
✕Less likely to help
Patients who are not overweight or do not have metabolic disorders may not receive any benefit from this research.
What this research studies
This research investigates innovative chimeric peptides that can simultaneously target multiple receptors involved in regulating appetite and glucose levels. By focusing on the interconnected pathways that contribute to obesity, the study aims to develop a new class of therapeutics that can effectively reduce food intake and improve metabolic health. The approach includes testing a tri-agonist peptide, GEP44, which has shown promising results in animal models by significantly decreasing appetite and body weight without causing common side effects. Patients may benefit from these new treatments if they are effective in human trials.
Why it matters
Potential benefit: If successful, this research could lead to more effective obesity treatments that significantly reduce appetite and improve blood sugar control.
How similar studies have gone: Other research has shown success with similar multi-target approaches in obesity treatment, indicating potential for this novel strategy.
Where this research is happening
-
Seattle Children's Hospital
Seattle, United States Active
Researchers
- Principal investigator: Roth, Christian Ludwig — Seattle Children's Hospital
- Study coordinator: Roth, Christian Ludwig
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.