Creating new trachea parts for children with airway defects
Tissue-engineered trachea composites for long-segment airway replacement (DIVERSITY SUPP - Hussein)
This study is exploring a new way to help kids with damaged tracheas by creating special grafts that can support healing and improve breathing, and they’re testing these grafts in mice to see how well they work.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Research Inst Nationwide Children's Hosp NIH-funded |
| Lab location | 1 site (Columbus, United States) |
| Project ID | NIH-10938480 on NIH RePORTER |
What this research studies
This research focuses on developing a new method to replace damaged sections of the trachea in children who suffer from long-segment airway defects due to congenital issues or trauma. The team is using tissue engineering techniques to create composite tracheal grafts that can better support airway function and promote healing. By testing these grafts in a mouse model, the researchers aim to improve survival rates and reduce complications associated with current surgical options. The study will evaluate how well these grafts can regenerate necessary tissue and maintain structural integrity.
Who could benefit from this research
Good fit: Ideal candidates for this research are children under 11 years old who have long-segment airway defects.
Not a fit: Patients with short-segment airway defects or those who do not require surgical intervention may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to safer and more effective treatments for children with severe airway defects, potentially saving lives.
How similar studies have performed: While tissue engineering for airway reconstruction is a developing field, previous studies have shown promise in using similar approaches, although this specific method is novel.
Where this research is happening
Columbus, United States
- Research Inst Nationwide Children's Hosp — Columbus, United States (Active)
Researchers
- Principal investigator: Chiang, Tendy — Research Inst Nationwide Children's Hosp
- Study coordinator: Chiang, Tendy
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.