Creating new tools to study a key receptor involved in HIV and other diseases
Official title: Developing Novel Tools to Study Chemokine Receptor Ccr5 Expression and Function in Mice
Funded at Icahn School of Medicine at Mount Sinai · NIH-11099987 · Data updated 2026-11-12
This study is looking at a protein called CCR5 that is important for understanding HIV and other diseases, and by creating special mice and antibodies, the researchers hope to learn more about how CCR5 works, which could help in finding new treatments for infections like West Nile virus.
Quick facts
| Grant type | R03 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Icahn School of Medicine at Mount Sinai NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | June 1, 2024 |
| Project end | April 30, 2026 |
| Funding year | 2025 |
| Award (this year) | $84,500 |
| NIH project number | 5R03AI182613-02 |
| Project ID | NIH-11099987 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals affected by HIV or those with conditions related to CCR5 dysfunction.
✕Less likely to help
Patients who do not have HIV or related inflammatory conditions may not benefit from this research.
What this research studies
This research focuses on the CCR5 chemokine receptor, which plays a crucial role in HIV infection and other diseases. The team aims to develop a specialized mouse model and specific antibodies to better understand how CCR5 functions and its expression in various conditions. By creating these tools, researchers hope to explore the implications of CCR5 in diseases like West Nile virus and other neurotropic infections. This work will enhance our understanding of CCR5's role in health and disease, potentially leading to new therapeutic strategies.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for HIV and other diseases linked to CCR5.
How similar studies have gone: Previous research has shown promising results in targeting CCR5 for HIV treatment, indicating potential for success in this novel approach.
Where this research is happening
-
Icahn School of Medicine at Mount Sinai
New York, United States Active
Researchers
- Principal investigator: Lim, Jean Kyou — Icahn School of Medicine at Mount Sinai
- Study coordinator: Lim, Jean Kyou
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.