Creating new tools to control brain cell activity with light
Development of photocaged DREADD agonists for high-efficiency, target-specific optical silencing of synaptic transmission
['FUNDING_R01'] · UNIVERSITY OF CALIFORNIA, SAN DIEGO · NIH-11013516
This study is all about creating new tools that let scientists use light to control certain brain cells, which could help us better understand how the brain works and influences behavior.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF CALIFORNIA, SAN DIEGO (nih funded) |
| Locations | 1 site (LA JOLLA, UNITED STATES) |
| Trial ID | NIH-11013516 on ClinicalTrials.gov |
What this research studies
This research focuses on developing innovative tools that allow scientists to control the activity of specific brain cells using light. By creating 'photo-caged' DREADD agonists, the researchers aim to enable precise silencing of synaptic transmission in targeted areas of the brain. This method involves applying these tools in an inactive form and activating them with light, which allows for high temporal precision in controlling neural activity. The goal is to improve the effectiveness and usability of these tools in neuroscience research, ultimately enhancing our understanding of brain function and behavior.
Who could benefit from this research
Good fit: Ideal candidates for this research would be individuals with neurological conditions that could benefit from targeted neural modulation.
Not a fit: Patients with conditions unrelated to neural activity or those who do not have access to the necessary technology may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatments for neurological disorders by providing better ways to manipulate brain activity.
How similar studies have performed: Previous research has shown promise in using optogenetic and chemogenetic tools for neural modulation, indicating that this approach could be a significant advancement in the field.
Where this research is happening
LA JOLLA, UNITED STATES
- UNIVERSITY OF CALIFORNIA, SAN DIEGO — LA JOLLA, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: BANGHART, MATTHEW R. — UNIVERSITY OF CALIFORNIA, SAN DIEGO
- Study coordinator: BANGHART, MATTHEW R.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.