Creating new tests to understand bone health and aging in cancer survivors
Official title: Develop and validate demineralized bone paper-based human bone metabolic and senolytic assays
Funded at University of Massachusetts Amherst · NIH-10921106 · Data updated 2026-11-12
This study is looking at new ways to understand how aging affects bones in cancer survivors and how certain drugs might help, using a special material that acts like real bone to test these ideas.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Massachusetts Amherst NIH-funded |
| Lab location | 1 site (Hadley, United States) |
| Project start | August 1, 2024 |
| Project end | July 31, 2027 |
| Funding year | 2024 |
| Award (this year) | $394,482 |
| NIH project number | 1R33CA291301-01 |
| Project ID | NIH-10921106 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are cancer survivors who are experiencing or at risk for bone metastasis and related complications.
✕Less likely to help
Patients who do not have a history of cancer or those without concerns related to bone health may not benefit from this research.
What this research studies
This research focuses on developing innovative assays using demineralized bone paper to study bone metabolism and the effects of senolytic drugs in cancer survivors. By creating humanized models that mimic bone tissue, the research aims to better understand how aging and cellular senescence contribute to bone metastasis. The approach involves using a unique material that preserves the structure of bone while allowing for detailed analysis and testing of potential treatments. This could lead to improved strategies for preventing bone-related complications in cancer survivors.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatments for preventing bone metastasis and improving bone health in cancer survivors.
How similar studies have gone: Other research has shown promise in using similar approaches to study bone health and aging, indicating potential for success in this area.
Where this research is happening
-
University of Massachusetts Amherst
Hadley, United States Active
Researchers
- Principal investigator: Lee, Jungwoo — University of Massachusetts Amherst
- Study coordinator: Lee, Jungwoo
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.