Creating new skin flaps for reconstructive surgery
Development of engineered fasciocutaneous skin flaps
This study is working on creating special skin flaps using your own cells to help heal tough wounds from things like birth defects, injuries, or cancer, making surgeries more successful for people who need help with tissue repair.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Massachusetts General Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-11079600 on NIH RePORTER |
What this research studies
This research focuses on developing engineered fasciocutaneous skin flaps to address complex tissue defects caused by birth defects, trauma, or cancer. The approach aims to create vascularized and blood-compatible flaps using patient-specific cells, which could improve the outcomes of reconstructive surgeries. By overcoming the limitations of current techniques, this project seeks to provide a more effective solution for patients with challenging tissue repair needs. The methodology involves innovative engineering protocols to enhance the viability and functionality of these skin flaps.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with severe tissue defects due to birth defects, trauma, or cancer.
Not a fit: Patients with minor tissue defects or those who do not require reconstructive surgery may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could significantly improve reconstructive surgery outcomes for patients with complex tissue defects.
How similar studies have performed: Previous research has shown promise in the field of engineered tissue flaps, indicating potential for success with this novel approach.
Where this research is happening
Boston, United States
- Massachusetts General Hospital — Boston, United States (Active)
Researchers
- Principal investigator: Uygun, Basak Elif — Massachusetts General Hospital
- Study coordinator: Uygun, Basak Elif
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.