Creating new skin flaps for reconstructive surgery
Official title: Development of engineered fasciocutaneous skin flaps
Funded at Massachusetts General Hospital · NIH-11079600 · Data updated 2026-11-12
This study is working on creating special skin flaps using your own cells to help heal tough wounds from things like birth defects, injuries, or cancer, making surgeries more successful for people who need help with tissue repair.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Massachusetts General Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project start | July 15, 2023 |
| Project end | April 30, 2028 |
| Funding year | 2025 |
| Award (this year) | $356,378 |
| NIH project number | 5R01AR082825-03 |
| Project ID | NIH-11079600 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals with severe tissue defects due to birth defects, trauma, or cancer.
✕Less likely to help
Patients with minor tissue defects or those who do not require reconstructive surgery may not benefit from this research.
What this research studies
This research focuses on developing engineered fasciocutaneous skin flaps to address complex tissue defects caused by birth defects, trauma, or cancer. The approach aims to create vascularized and blood-compatible flaps using patient-specific cells, which could improve the outcomes of reconstructive surgeries. By overcoming the limitations of current techniques, this project seeks to provide a more effective solution for patients with challenging tissue repair needs. The methodology involves innovative engineering protocols to enhance the viability and functionality of these skin flaps.
Why it matters
Potential benefit: If successful, this research could significantly improve reconstructive surgery outcomes for patients with complex tissue defects.
How similar studies have gone: Previous research has shown promise in the field of engineered tissue flaps, indicating potential for success with this novel approach.
Where this research is happening
-
Massachusetts General Hospital
Boston, United States Active
Researchers
- Principal investigator: Uygun, Basak Elif — Massachusetts General Hospital
- Study coordinator: Uygun, Basak Elif
Related research
Other NIH-funded projects on the same topics.
-
Global TravEpiNet: Pregnant Travelers Health and Disease Prevention Network
This grant supports a national network to improve health and prevent infections among international travelers, with a special focus on pregnant travelers.
-
Soluble ST2 and the course of lung injury in ARDS
A doctor-scientist at a top hospital is studying how a molecule called soluble ST2 may influence how lung injury starts and heals in patients with ARDS and related conditions.
-
Role of airway macrophages in lung health and allergic disease
A doctor-scientist at a major hospital wants to study how immune cells in the airways develop and influence asthma and other airway diseases.
-
Global TravEpiNet: Understanding and Protecting US Travelers, including Pregnant Travelers
A large U.S. network studies international travelers, including pregnant travelers, to understand illness risks and reduce the spread of infections.
-
Gait speed from wearable sensors to guide ALS trials
A patient-friendly look at using wearable sensors to measure how fast people with ALS walk, to help run better ALS trials.
-
Determinants of Post-Stroke Cognitive Outcomes and Vascular Effects on Recovery
A large, multi-site effort aims to understand why some stroke survivors develop long-term cognitive problems and dementia, and how vascular health and pre-existing brain changes influence recovery.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.