Creating new proteins that can bind metal cofactors for chemical reactions
De novo design of functional metallocofactor-binding proteins
This study is all about creating new proteins that can help make better medicines by controlling how certain chemicals react, which could lead to improved treatments for patients.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California Riverside NIH-funded |
| Lab location | 1 site (Riverside, United States) |
| Project ID | NIH-11092399 on NIH RePORTER |
What this research studies
This research focuses on designing new metalloenzymes, which are proteins that can bind metal cofactors and perform specific chemical reactions. By understanding how these proteins work, the research aims to create proteins from scratch that can stabilize powerful oxidants and control their reactivity. The approach involves using computational methods to design proteins with specific structures that enhance their ability to bind substrates and influence the outcome of chemical reactions. Patients may benefit from advancements in drug development and therapies that utilize these engineered proteins.
Who could benefit from this research
Good fit: Ideal candidates for participation or benefit from this research would include individuals with conditions that could be treated by new anti-inflammatory agents or other drugs developed from these engineered proteins.
Not a fit: Patients with conditions unrelated to the biochemical pathways targeted by these engineered proteins may not receive any benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to the development of novel therapies and drugs that utilize engineered proteins for improved treatment options.
How similar studies have performed: Other research has shown success in designing proteins with specific functions, indicating that this approach has potential for breakthroughs in therapeutic applications.
Where this research is happening
Riverside, United States
- University of California Riverside — Riverside, United States (Active)
Researchers
- Principal investigator: Mann, Samuel I — University of California Riverside
- Study coordinator: Mann, Samuel I
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.