Creating new pain relief medications that target LPA5 receptors
Official title: Development of LPA5 Antagonists as Analgesics
Funded at Research Triangle Institute · NIH-10638278 · Data updated 2026-11-12
This study is looking for new pain relief options for people with nerve pain, like those with nerve injuries or multiple sclerosis, by testing medications that work differently than opioids, aiming to help you manage pain safely without the risk of addiction.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Research Triangle Institute NIH-funded |
| Lab location | 1 site (Research Triangle Park, United States) |
| Project start | July 6, 2023 |
| Project end | June 30, 2025 |
| Funding year | 2023 |
| Award (this year) | $1,881,741 |
| NIH project number | 1R61NS131188-01 |
| Project ID | NIH-10638278 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals experiencing neuropathic pain due to conditions such as nerve injury or multiple sclerosis.
✕Less likely to help
Patients who do not suffer from neuropathic pain or have other types of pain not related to the LPA5 receptor may not benefit from this research.
What this research studies
This research focuses on developing new medications that can effectively relieve neuropathic pain without the risks associated with opioids. It investigates the role of the LPA5 receptor, which is involved in pain processing, particularly in conditions like nerve injury and multiple sclerosis. By blocking this receptor with specific antagonists, the research aims to provide safer alternatives for pain management. Patients may benefit from a new class of analgesics that do not lead to dependence or abuse.
Why it matters
Potential benefit: If successful, this research could lead to safer, non-opioid pain relief options for patients suffering from neuropathic pain.
How similar studies have gone: Previous research has shown promise in targeting LPA5 for pain relief, indicating that this approach could be a viable option for developing new analgesics.
Where this research is happening
-
Research Triangle Institute
Research Triangle Park, United States Active
Researchers
- Principal investigator: Zhang, Yanan — Research Triangle Institute
- Study coordinator: Zhang, Yanan
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.