Creating New Muscle Cells from Human Stem Cells
Reprogramming and Directed Differentiation of Skeletal Muscle Cells from hPSCs
This work uses human stem cells to grow and understand muscle cells, hoping to find new ways to treat muscle diseases.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California Los Angeles NIH-funded |
| Lab location | 1 site (Los Angeles, United States) |
| Project ID | NIH-11113996 on NIH RePORTER |
What this research studies
This project uses special human stem cells to learn how muscle cells develop and to create models of muscle diseases in the lab. Researchers are working to improve how these lab-grown muscle cells and adult muscle stem cells can be guided to become healthy, functional muscle. The goal is to better understand how muscle cells change over time and to develop stronger, more effective cells for future treatments. This builds on earlier discoveries about human muscle development.
Who could benefit from this research
Good fit: This foundational research does not directly recruit patients but aims to benefit those with muscle diseases, particularly those involving muscle stem cell dysfunction.
Not a fit: Patients without muscle-related conditions or those seeking immediate treatment options would not directly benefit from this early-stage research.
Why it matters
Potential benefit: If successful, this work could lead to new cell therapies or improved understanding for treating muscle-wasting conditions like Duchenne Muscular Dystrophy.
How similar studies have performed: This project builds upon previous successful work by the same team in understanding human muscle development from stem cells, indicating a foundation of prior success.
Where this research is happening
Los Angeles, United States
- University of California Los Angeles — Los Angeles, United States (Active)
Researchers
- Principal investigator: Pyle, April D — University of California Los Angeles
- Study coordinator: Pyle, April D
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.