Creating new mRNA vaccines to protect against whooping cough
Development of mRNA-platform vaccines
This study is testing new mRNA vaccines to help protect against whooping cough by boosting your immune response, and it’s looking for people to help try out these promising vaccines.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | West Virginia University NIH-funded |
| Lab location | 1 site (Morgantown, United States) |
| Project ID | NIH-11000763 on NIH RePORTER |
What this research studies
This research focuses on developing innovative mRNA vaccines aimed at providing better immunity against whooping cough, a respiratory disease caused by Bordetella pertussis. The approach involves identifying multiple antigens from the bacteria to enhance the immune response, particularly targeting T helper 1 (Th1) responses, which are crucial for long-lasting protection. By utilizing an mRNA platform, the researchers can quickly adapt the vaccine to include various antigens, potentially improving the effectiveness compared to existing vaccines. Patients may be involved in trials to assess the safety and efficacy of these new vaccines.
Who could benefit from this research
Good fit: Ideal candidates for participation or benefit from this research include children and adults who are at risk of contracting whooping cough, particularly those who have not received adequate vaccination.
Not a fit: Patients who have already developed immunity to whooping cough or those who are not at risk of the disease may not receive any benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective vaccines that provide longer-lasting immunity against whooping cough, reducing the incidence of the disease.
How similar studies have performed: Previous research on mRNA vaccines has shown promising results in other infectious diseases, indicating a strong potential for success in this novel approach.
Where this research is happening
Morgantown, United States
- West Virginia University — Morgantown, United States (Active)
Researchers
- Principal investigator: Damron, Fredrick Heath — West Virginia University
- Study coordinator: Damron, Fredrick Heath
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.