Creating new mouse models to study male hormonal changes and dementia
Developing new mouse models of andropause for ADRD research
This study is creating special mouse models to help us understand how lower testosterone levels in older men might be connected to memory problems and Alzheimer's disease, so we can learn more about how aging affects brain health.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Albany Medical College NIH-funded |
| Lab location | 1 site (Albany, United States) |
| Project ID | NIH-10984772 on NIH RePORTER |
What this research studies
This research focuses on developing new mouse models that simulate andropause, a condition characterized by declining testosterone levels in aging men. The researchers aim to create models that better reflect the hormonal changes associated with aging and their potential link to Alzheimer's disease and related dementias. By studying these models, they hope to understand how reduced androgen levels may contribute to cognitive decline and increase the risk of dementia. The approach includes both surgical and non-surgical methods to replicate the hormonal environment seen in humans.
Who could benefit from this research
Good fit: Ideal candidates for this research are older men, particularly those over 45, who may be experiencing symptoms related to low testosterone levels.
Not a fit: Patients who are not male or those who do not have concerns related to hormonal changes or cognitive decline may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to better understanding and treatment options for men experiencing cognitive decline related to hormonal changes.
How similar studies have performed: While there has been significant research on menopause models, the development of accurate models for andropause is relatively novel and has not been extensively tested.
Where this research is happening
Albany, United States
- Albany Medical College — Albany, United States (Active)
Researchers
- Principal investigator: Zuloaga, Kristen Leanne — Albany Medical College
- Study coordinator: Zuloaga, Kristen Leanne
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.