Creating new mouse models to study diseases more effectively
The Unilateral Mosaic (UMos): Novel tools to compartmentalize pathology and trace cellular interactions in mouse models of human disease
['FUNDING_R21'] · CORNELL UNIVERSITY · NIH-11039141
This study is creating special mouse models that help scientists understand how diseases develop by comparing healthy and unhealthy lung tissues in the same mouse, which could lead to better insights into how diseases work and how cells interact.
Quick facts
| Phase | ['FUNDING_R21'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | CORNELL UNIVERSITY (nih funded) |
| Locations | 1 site (ITHACA, UNITED STATES) |
| Trial ID | NIH-11039141 on ClinicalTrials.gov |
What this research studies
This research develops innovative mouse models that allow scientists to study disease processes by creating areas of disease-prone and disease-resistant tissue within the same animal. By using a technique called Unilateral Mosaic, researchers can express genes that affect disease susceptibility in only one side of the lungs, providing a unique opportunity to compare healthy and diseased tissues side by side. Additionally, the study introduces a method for tracing cellular interactions in living mice, which could enhance our understanding of how diseases progress and how cells communicate. These models aim to reduce variability in research and improve the accuracy of findings related to complex human diseases.
Who could benefit from this research
Good fit: Ideal candidates for benefiting from this research include individuals with conditions that are studied using mouse models, such as autoimmune diseases or cancers.
Not a fit: Patients with conditions that do not have corresponding mouse models or those not involved in research settings may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more precise models for studying diseases, ultimately improving treatment strategies for patients.
How similar studies have performed: Other research has shown success with similar innovative mouse modeling techniques, indicating a promising avenue for advancing our understanding of human diseases.
Where this research is happening
ITHACA, UNITED STATES
- CORNELL UNIVERSITY — ITHACA, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: GLUDISH, DAVID W — CORNELL UNIVERSITY
- Study coordinator: GLUDISH, DAVID W
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.