Creating new mouse models to improve antibody treatments for cancer
Novel Transgenic Mouse Models Addressing Outstanding Translational Barriers in Antibody-Based Therapeutics
This study is creating special mouse models that act more like humans to help researchers test new cancer treatments using antibodies, which could lead to better therapies for people with cancer.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Rockefeller University NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-10880290 on NIH RePORTER |
What this research studies
This research focuses on developing innovative mouse models that can better mimic human responses to antibody-based cancer therapies. By engineering these models to express human proteins, the researchers aim to enhance the testing of monoclonal antibodies, which are crucial for targeting cancer cells. The study addresses current limitations in preclinical testing, such as the rejection of human antibodies in traditional animal models. This approach could lead to more effective treatments by providing a better understanding of how these therapies work in a living organism.
Who could benefit from this research
Good fit: Ideal candidates for benefiting from this research include patients with various types of cancer who may be treated with antibody-based therapies.
Not a fit: Patients who do not have cancer or are not candidates for antibody therapies may not receive any benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective antibody therapies for cancer patients.
How similar studies have performed: Other research has shown success in using engineered animal models to improve the efficacy of antibody therapies, indicating that this approach has potential.
Where this research is happening
New York, United States
- Rockefeller University — New York, United States (Active)
Researchers
- Principal investigator: Bournazos, Stylianos — Rockefeller University
- Study coordinator: Bournazos, Stylianos
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.