Creating new molecules to study protein modifications
Official title: Chemoenzymatic Synthesis of Libraries of Sulfoglycopeptides
Funded at University of Mississippi · NIH-11127729 · Data updated 2026-11-12
This study is looking at how certain changes to proteins can affect how they work in our bodies, which could help us understand more about health and disease.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Mississippi NIH-funded |
| Lab location | 1 site (University, United States) |
| Project start | July 1, 2024 |
| Project end | May 31, 2029 |
| Funding year | 2025 |
| Award (this year) | $357,646 |
| NIH project number | 5R35GM155126-02 |
| Project ID | NIH-11127729 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with conditions related to protein signaling and adhesion, such as certain cancers or autoimmune diseases.
✕Less likely to help
Patients with conditions unrelated to protein modifications or those not affected by cell signaling pathways may not benefit from this research.
What this research studies
This research focuses on understanding how specific modifications to proteins, known as O-glycosylation and Tyrosine sulfation, affect their function in biological systems. By synthesizing a variety of these modified molecules, the researchers aim to explore how they influence cell signaling and communication. The approach combines synthetic chemistry with computational methods to predict how these molecules interact with each other and their targets. This could lead to new insights into the roles of these modifications in health and disease.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies by enhancing our understanding of protein interactions and signaling pathways.
How similar studies have gone: While the specific approach of synthesizing these molecules is novel, similar research in protein modifications has shown promising results in understanding cellular processes.
Where this research is happening
-
University of Mississippi
University, United States Active
Researchers
- Principal investigator: Zhu, Hailiang Joshua — University of Mississippi
- Study coordinator: Zhu, Hailiang Joshua
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.