Creating new models to understand heart cell defects in a specific heart condition
Official title: Novel bioengineering models to dissect cardiac cell-cell defects in arrhythmogenic cardiomyopathy
Funded at Icahn School of Medicine at Mount Sinai · NIH-10827986 · Data updated 2026-11-12
This study is creating a new model to help us understand arrhythmogenic cardiomyopathy (ACM), a heart condition that can cause serious rhythm issues, so we can find better treatments for people living with it.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Icahn School of Medicine at Mount Sinai NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | April 12, 2023 |
| Project end | March 31, 2026 |
| Funding year | 2024 |
| Award (this year) | $253,500 |
| NIH project number | 5R21HL165298-02 |
| Project ID | NIH-10827986 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with arrhythmogenic cardiomyopathy or those at risk of developing this condition.
✕Less likely to help
Patients with heart conditions unrelated to arrhythmogenic cardiomyopathy may not benefit from this research.
What this research studies
This research focuses on arrhythmogenic cardiomyopathy (ACM), a condition that leads to heart rhythm problems and can cause sudden death. The team aims to develop a novel human model that mimics the fibrofatty infiltration seen in ACM, which disrupts normal heart function. By integrating engineering and biomedical sciences, they will use advanced techniques such as tissue engineering and stem cell technologies to replicate the disease's effects in a controlled environment. This model will help researchers better understand the mechanisms behind ACM and explore potential therapies.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for patients suffering from arrhythmogenic cardiomyopathy and related heart conditions.
How similar studies have gone: While this approach is innovative, similar research has shown promise in developing models for other cardiac conditions, indicating potential for success.
Where this research is happening
-
Icahn School of Medicine at Mount Sinai
New York, United States Active
Researchers
- Principal investigator: Cal Y Mayor-Turnbull, Irene — Icahn School of Medicine at Mount Sinai
- Study coordinator: Cal Y Mayor-Turnbull, Irene
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.