Creating new models to understand brain blood vessel diseases and related cognitive issues
Development and validation of novel models for cerebral small vessel disease and vascular cognitive impairment
['FUNDING_OTHER'] · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · NIH-10684902
This study is creating new mouse models to help us understand how problems with blood vessels in the brain can lead to memory and thinking issues, with the goal of finding better ways to prevent and treat these conditions in people.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF CALIFORNIA, SAN FRANCISCO (nih funded) |
| Locations | 1 site (SAN FRANCISCO, UNITED STATES) |
| Trial ID | NIH-10684902 on ClinicalTrials.gov |
What this research studies
This research focuses on vascular cognitive impairment and dementia (VCID), which are cognitive changes linked to problems in the brain's blood vessels. The team aims to develop and validate five new mouse models that mimic human diseases caused by cerebral small vessel diseases (cSVDs). By using advanced techniques such as genetic analysis, imaging, and behavioral tests, the researchers hope to better understand the mechanisms behind these conditions. This understanding could lead to improved prevention and treatment strategies for patients affected by VCID.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals experiencing cognitive decline related to vascular issues, particularly older adults.
Not a fit: Patients with cognitive impairment not related to vascular conditions or those with other forms of dementia may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new insights and therapies for patients suffering from vascular cognitive impairment and dementia.
How similar studies have performed: Previous research has shown promise in developing animal models for similar vascular cognitive impairments, indicating a potential for success in this novel approach.
Where this research is happening
SAN FRANCISCO, UNITED STATES
- UNIVERSITY OF CALIFORNIA, SAN FRANCISCO — SAN FRANCISCO, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: GOULD, DOUGLAS — UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
- Study coordinator: GOULD, DOUGLAS
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Alzheimer disease dementia, Alzheimer syndrome, Alzheimer's Disease