Creating new methods to synthesize complex chemical structures.
Official title: Methods for Enantioselective Spirocycle Synthesis and Radical Hydroamination of Trisubstituted Alkenes
Funded at California Institute of Technology · NIH-10913602 · Data updated 2026-11-12
This study is exploring new ways to create special chemical compounds that could help in making better medicines, especially for treating different health conditions.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | California Institute of Technology NIH-funded |
| Lab location | 1 site (Pasadena, United States) |
| Project start | September 1, 2023 |
| Project end | August 31, 2025 |
| Funding year | 2024 |
| Award (this year) | $120,767 |
| NIH project number | 5K99GM152819-02 |
| Project ID | NIH-10913602 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for benefiting from this research are individuals with conditions that could be treated by new drugs derived from the synthesized compounds.
✕Less likely to help
Patients who are not affected by conditions treatable with the newly developed compounds may not receive any benefit from this research.
What this research studies
This research investigates innovative techniques for synthesizing spirocyclic compounds and performing radical hydroamination on specific alkenes. By combining experimental methods with computational analysis, the project aims to enhance the understanding of chemical reactions and improve the design of new synthetic pathways. The focus is on developing enantioselective methods that can produce complex molecules with potential medicinal properties, particularly those containing quaternary stereocenters. This could lead to the creation of new drugs or therapies that are more effective in treating various conditions.
Why it matters
Potential benefit: If successful, this research could lead to the development of new medications with improved efficacy and fewer side effects.
How similar studies have gone: Other research has shown promise in using similar synthetic methods to develop effective therapeutic agents, indicating a potential for success in this area.
Where this research is happening
-
California Institute of Technology
Pasadena, United States Active
Researchers
- Principal investigator: Ramirez, Melissa — California Institute of Technology
- Study coordinator: Ramirez, Melissa
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.