Creating new methods to quickly study genetic variations and their effects on diseases
Official title: Development of scalable methods for rapid phenotyping and functional testing of variants
Funded at Oklahoma Medical Research Foundation · NIH-10782895 · Data updated 2026-11-12
This study is looking at how certain genetic changes can lead to diseases by using zebrafish to help us understand these changes better, which could eventually lead to improved ways to diagnose and treat genetic disorders that affect people like you.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Oklahoma Medical Research Foundation NIH-funded |
| Lab location | 1 site (Oklahoma City, United States) |
| Project start | July 15, 2024 |
| Project end | June 30, 2028 |
| Funding year | 2024 |
| Award (this year) | $607,682 |
| NIH project number | 1R24OD034438-01A1 |
| Project ID | NIH-10782895 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for participation or benefit from this research include individuals with genetic disorders or those interested in genetic research.
✕Less likely to help
Patients with conditions unrelated to genetic variations or those not interested in genetic research may not receive benefit from this research.
What this research studies
This research focuses on understanding how specific genetic variations contribute to human diseases by using zebrafish as a model organism. Researchers will develop a high-throughput system to rapidly analyze the effects of these genetic variations, utilizing advanced CRISPR technology to create precise genetic modifications. By generating and testing various genetic mutations, the project aims to uncover the biological mechanisms behind diseases, which could lead to better diagnostic and therapeutic strategies. Patients may benefit from insights gained through this research, as it could enhance our understanding of genetic disorders.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and treatment options for genetic diseases.
How similar studies have gone: Other research using CRISPR technology in zebrafish has shown promise in understanding genetic diseases, indicating that this approach has potential for success.
Where this research is happening
-
Oklahoma Medical Research Foundation
Oklahoma City, United States Active
Researchers
- Principal investigator: Varshney, Gaurav K — Oklahoma Medical Research Foundation
- Study coordinator: Varshney, Gaurav K
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.