Creating new methods to change how proteins interact in the body
Official title: Development of evolutionary technologies to reprogram protein-protein interactions
Funded at University of Chicago · NIH-10975955 · Data updated 2026-11-12
This study is exploring new ways to change how proteins interact in the body, which could help create better treatments for tough-to-treat diseases, giving patients hope for more effective options.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Chicago NIH-funded |
| Lab location | 1 site (Chicago, United States) |
| Project start | November 16, 2022 |
| Project end | November 15, 2025 |
| Funding year | 2025 |
| Award (this year) | $76,756 |
| NIH project number | 5F32GM147968-03 |
| Project ID | NIH-10975955 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with diseases linked to dysregulated protein-protein interactions, such as certain cancers.
✕Less likely to help
Patients with conditions unrelated to protein-protein interactions may not benefit from this research.
What this research studies
This research focuses on developing innovative technologies to alter protein-protein interactions (PPIs), which are crucial for many biological processes and disease states. By identifying and targeting these interactions, the project aims to create new therapeutic options for conditions that are currently difficult to treat. The approach involves using advanced techniques to quickly discover and validate molecular probes that can disrupt harmful PPIs, potentially leading to faster and more effective drug development. Patients may benefit from new treatments that target the underlying mechanisms of their diseases more effectively.
Why it matters
Potential benefit: If successful, this research could lead to the development of new therapies for diseases that are currently hard to treat due to challenging protein interactions.
How similar studies have gone: Other research has shown promise in targeting protein-protein interactions, indicating that this approach could lead to significant advancements in treatment options.
Where this research is happening
-
University of Chicago
Chicago, United States Active
Researchers
- Principal investigator: Styles, Matthew J — University of Chicago
- Study coordinator: Styles, Matthew J
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.