Creating new methods to build complex bioactive molecules and protein conjugates
Official title: Novel Acylborons and Alpha-hydroxy Borons to Enable Modular, Regio- and Stereocontrolled Synthesis of Bioactive Molecules and Protein Conjugates
Funded at The Trustees of the Stevens Institute of Technology · NIH-10877095 · Data updated 2026-11-12
This study is exploring new ways to create special molecules that could help develop better medicines, which might lead to new treatments for patients.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | The Trustees of the Stevens Institute of Technology NIH-funded |
| Lab location | 1 site (Hoboken, United States) |
| Project start | August 1, 2021 |
| Project end | July 31, 2026 |
| Funding year | 2024 |
| Award (this year) | $373,865 |
| NIH project number | 5R35GM143091-04 |
| Project ID | NIH-10877095 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for participation or benefit from this research would be individuals with conditions that could be treated by novel bioactive molecules or protein conjugates.
✕Less likely to help
Patients with conditions that do not involve the need for new drug development or those not affected by the types of molecules being synthesized may not receive any benefit.
What this research studies
This research focuses on developing innovative strategies to synthesize complex molecules that can be used in medicine. By using modular synthetic techniques, the project aims to create new types of organoborons, which are important building blocks for bioactive compounds. The approach involves constructing these molecules in a controlled manner to enhance their biological activity, potentially leading to new therapeutic options. Patients may benefit from advancements in drug discovery and development stemming from these novel compounds.
Why it matters
Potential benefit: If successful, this research could lead to the development of new and more effective drugs for various medical conditions.
How similar studies have gone: While the specific approach of using acylborons is relatively novel, similar modular synthesis strategies have shown promise in other areas of drug discovery.
Where this research is happening
-
The Trustees of the Stevens Institute of Technology
Hoboken, United States Active
Researchers
- Principal investigator: Sharma, Abhishek — The Trustees of the Stevens Institute of Technology
- Study coordinator: Sharma, Abhishek
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.