Creating new methods for making specific chemical compounds.
Official title: Development, Elucidation, and Application of New Principles in Stereoselective Catalysis
Funded at Harvard University · NIH-11045686 · Data updated 2026-11-12
This study is all about creating new, eco-friendly ways to make important chemical compounds that can help in medicine, using special tiny catalysts to ensure the process is both efficient and precise.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Harvard University NIH-funded |
| Lab location | 1 site (Cambridge, United States) |
| Project start | April 1, 2023 |
| Project end | March 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $914,773 |
| NIH project number | 5R35GM149244-03 |
| Project ID | NIH-11045686 on NIH RePORTER |
Who could benefit from this research
✓Could help
Patients who may benefit from this research include those requiring new or improved medications derived from chiral compounds.
✕Less likely to help
Patients with conditions that do not involve the use of chiral bioactive compounds may not receive any benefit from this research.
What this research studies
This research focuses on developing innovative catalytic reactions that are environmentally friendly and can produce chiral, bioactive compounds. By utilizing small-molecule, chiral organic catalysts, the project aims to enhance the efficiency and selectivity of chemical synthesis. The researchers will explore various catalytic concepts over five years, applying specially designed catalysts to facilitate complex bond formations while controlling the stereochemistry of the reactions. This work could lead to more effective and sustainable methods for producing important chemical substances.
Why it matters
Potential benefit: If successful, this research could lead to more efficient and sustainable production of essential pharmaceuticals and other bioactive compounds.
How similar studies have gone: Previous research has shown success in developing catalytic methods for chemical synthesis, indicating that this approach has potential for significant advancements.
Where this research is happening
-
Harvard University
Cambridge, United States Active
Researchers
- Principal investigator: Jacobsen, Eric N — Harvard University
- Study coordinator: Jacobsen, Eric N
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.