Creating new medicines using high pressure techniques
Green Synthesis of Building Blocks and APIs by High Hydrostatic Pressure-initiated Synthesis
This study is looking at how using high pressure can help make important ingredients for medicines more efficiently, which could ultimately benefit both drug makers and patients.
Quick facts
| Grant type | R15 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Massachusetts Boston NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-11043604 on NIH RePORTER |
What this research studies
This research investigates how high hydrostatic pressure (HHP) can enhance chemical reactions to create important building blocks and active pharmaceutical ingredients (APIs). By using theoretical calculations, the team will identify which reactions are most effective under high pressure conditions. Selected reactions will then be tested experimentally to confirm their effectiveness and understand the impact of pressure on these processes. The goal is to develop a systematic approach that can lead to more efficient drug synthesis, potentially benefiting the pharmaceutical industry and patients alike.
Who could benefit from this research
Good fit: Patients who require analgesic medications, such as those suffering from chronic pain or conditions that necessitate pain management, would be ideal candidates to benefit from this research.
Not a fit: Patients who do not require analgesic medications or those with conditions that do not respond to traditional pain relief methods may not receive benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more efficient and environmentally friendly methods for producing pain relief medications and other important drugs.
How similar studies have performed: While the use of high hydrostatic pressure in chemical synthesis is established in the food industry, this specific application in drug synthesis is relatively novel and has not been extensively tested.
Where this research is happening
Boston, United States
- University of Massachusetts Boston — Boston, United States (Active)
Researchers
- Principal investigator: Torok, Bela — University of Massachusetts Boston
- Study coordinator: Torok, Bela
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.