Creating new medications to reduce inflammation in Alzheimer's disease
Developing Novel Soluble Epoxide Hydrolase Inhibitors for the Treatment of Alzheimer's Disease
This study is testing a new medication called EHI-16 that aims to reduce inflammation in the brain, which could help slow down Alzheimer's disease, and they are looking for patients to join trials to see how safe and effective it is.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Baylor College of Medicine NIH-funded |
| Lab location | 1 site (Houston, United States) |
| Project ID | NIH-10854854 on NIH RePORTER |
What this research studies
This research focuses on developing a new type of medication that targets inflammation in the brain, which is a significant factor in Alzheimer's disease. The team is working on a specific compound called EHI-16, which has shown promise in laboratory tests for its ability to penetrate the blood-brain barrier and reduce neuroinflammation. By optimizing this compound, the researchers aim to create a treatment that could potentially slow down or modify the progression of Alzheimer's disease. Patients may be involved in trials to assess the safety and effectiveness of this new therapy.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with Alzheimer's disease or those experiencing significant cognitive decline.
Not a fit: Patients with other forms of dementia or those who do not have Alzheimer's disease may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to a new treatment that modifies the course of Alzheimer's disease and improves cognitive function in patients.
How similar studies have performed: Previous research has shown that targeting neuroinflammation can be beneficial in treating Alzheimer's disease, indicating a promising avenue for this approach.
Where this research is happening
Houston, United States
- Baylor College of Medicine — Houston, United States (Active)
Researchers
- Principal investigator: Wang, Jin — Baylor College of Medicine
- Study coordinator: Wang, Jin
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.