Creating new imaging techniques to better understand brain injuries
Development of Novel Functional Markers for TBI Using Molecular MRI
This study is looking to make it easier to spot brain injuries by using a new type of MRI that can see tiny damage that regular scans might miss, helping doctors better understand how serious the injury is and how to treat it.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Johns Hopkins University NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project ID | NIH-10490321 on NIH RePORTER |
What this research studies
This research focuses on improving the diagnosis of traumatic brain injury (TBI) by developing advanced imaging techniques using molecular MRI. Current imaging methods like CT and standard MRI can miss important microscopic damage, especially in mild cases of TBI. The study utilizes amide proton transfer (APT) imaging to identify changes in brain tissue pH and protein levels, which may indicate injury severity and inflammation. By validating these techniques in various TBI models, the research aims to provide more accurate assessments of brain injuries.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals who have experienced a traumatic brain injury, particularly those with mild symptoms.
Not a fit: Patients with severe brain injuries that are already clearly identifiable through standard imaging techniques may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more accurate diagnoses and better treatment options for patients with traumatic brain injuries.
How similar studies have performed: Other research has shown promise in using advanced imaging techniques for brain injuries, suggesting that this approach could lead to significant advancements in TBI diagnosis.
Where this research is happening
Baltimore, United States
- Johns Hopkins University — Baltimore, United States (Active)
Researchers
- Principal investigator: Zhou, Jinyuan — Johns Hopkins University
- Study coordinator: Zhou, Jinyuan
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.