Creating new enzymes to build biological compounds
Engineering promiscuous enzymes for synthesis of biological building blocks
['FUNDING_OTHER'] · UNIVERSITY OF WISCONSIN-MADISON · NIH-10842118
This study is all about improving special proteins called enzymes that help make important building blocks for medicines, which could lead to better treatments for patients.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF WISCONSIN-MADISON (nih funded) |
| Locations | 1 site (MADISON, UNITED STATES) |
| Trial ID | NIH-10842118 on ClinicalTrials.gov |
What this research studies
This research focuses on engineering enzymes that can efficiently create carbon-carbon bonds, which are essential for synthesizing various biological building blocks. By studying specific enzymes that utilize pyridoxal phosphate, the team aims to understand their mechanisms and improve their functionality. The approach includes detailed structural and kinetic analyses, as well as innovative screening methods to enhance enzyme evolution. Patients may benefit from advancements in drug development and therapeutic compounds resulting from these engineered enzymes.
Who could benefit from this research
Good fit: Ideal candidates for benefiting from this research include individuals with conditions that could be treated by new therapeutic compounds developed through enhanced enzyme synthesis.
Not a fit: Patients with conditions that do not require new drug development or those not affected by metabolic disorders may not receive direct benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective and safer drugs by improving the synthesis of essential biological compounds.
How similar studies have performed: Other research has shown promise in engineering enzymes for improved synthesis, indicating that this approach has potential for success.
Where this research is happening
MADISON, UNITED STATES
- UNIVERSITY OF WISCONSIN-MADISON — MADISON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: BULLER, ANDREW — UNIVERSITY OF WISCONSIN-MADISON
- Study coordinator: BULLER, ANDREW
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.