Creating new enzymes to add halogens to small molecules for pharmaceuticals and agriculture
Engineering Halogenases for Small Molecule Functionalization and Enantioselective Catalysis
['FUNDING_OTHER'] · TRUSTEES OF INDIANA UNIVERSITY · NIH-11001996
This study is working on creating special enzymes that can help make better medicines and agricultural products by adding important halogen atoms to certain compounds, which could eventually lead to more effective treatments for patients like you.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | TRUSTEES OF INDIANA UNIVERSITY (nih funded) |
| Locations | 1 site (BLOOMINGTON, UNITED STATES) |
| Trial ID | NIH-11001996 on ClinicalTrials.gov |
What this research studies
This research focuses on developing specialized enzymes that can add halogen atoms to organic compounds, which are crucial for creating effective pharmaceuticals and agricultural chemicals. By engineering flavin-dependent halogenases and Fe(II)/α-ketoglutarate dependent halogenases, the project aims to enhance the selectivity and efficiency of halogenation reactions. Patients may benefit indirectly from this work as it could lead to the development of more effective medications and treatments derived from these halogenated compounds.
Who could benefit from this research
Good fit: Ideal candidates for benefiting from this research include individuals who require innovative treatments for diseases that could be addressed by new pharmaceuticals developed through these methods.
Not a fit: Patients with conditions that are not addressed by pharmaceuticals or agrochemicals may not receive any benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to the creation of more effective and targeted pharmaceuticals and agrochemicals, improving treatment options for various diseases.
How similar studies have performed: Other research has shown success in engineering enzymes for similar applications, indicating a promising avenue for further advancements.
Where this research is happening
BLOOMINGTON, UNITED STATES
- TRUSTEES OF INDIANA UNIVERSITY — BLOOMINGTON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: LEWIS, JARED C — TRUSTEES OF INDIANA UNIVERSITY
- Study coordinator: LEWIS, JARED C
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.