Creating new drugs to prevent blood clots in certain blood disorders
Developing small molecule inhibitors of Pleckstrin-2 to treat thrombosis
This study is looking for new medicines that can help prevent blood clots in people with certain blood disorders, aiming to make treatments safer and more effective for those affected.
Quick facts
| Grant type | Sbir 2 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Aplexis, INC. NIH-funded |
| Lab location | 1 site (Wilmette, United States) |
| Project ID | NIH-11051837 on NIH RePORTER |
What this research studies
This research focuses on developing small molecule inhibitors that target Pleckstrin-2, a protein involved in blood clotting, to treat thrombosis in patients with myeloproliferative neoplasms (MPNs). The approach aims to improve upon existing therapies, which are often inadequate and carry risks of complications. By collaborating with researchers at Northwestern University, the team is identifying compounds that could effectively inhibit this protein and reduce the incidence of thrombosis. The goal is to enhance patient outcomes and quality of life through more effective treatment options.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients diagnosed with myeloproliferative neoplasms who are at risk of thrombosis.
Not a fit: Patients without myeloproliferative neoplasms or those not experiencing thrombosis may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective therapies for preventing thrombosis in patients with MPNs, significantly improving their health and quality of life.
How similar studies have performed: Previous studies have shown promising results in targeting Pleckstrin-2 in animal models, indicating potential for success in human applications.
Where this research is happening
Wilmette, United States
- Aplexis, INC. — Wilmette, United States (Active)
Researchers
- Principal investigator: Yang, Jing — Aplexis, INC.
- Study coordinator: Yang, Jing
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.