Creating new drugs to help the brain recover after a stroke
Official title: Development and Characterization of Peptidomimetic Small Molecule Activators of Peptidase Neurolysin for Stroke Therapy
Funded at Oakland University · NIH-10753623 · Data updated 2026-11-12
This study is looking for new ways to help the brain heal after a stroke by creating small molecules that boost a natural protein called neurolysin, which helps with recovery, and it’s aimed at finding better treatments for stroke patients.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Oakland University NIH-funded |
| Lab location | 1 site (Rochester, United States) |
| Project start | January 1, 2023 |
| Project end | August 31, 2025 |
| Funding year | 2022 |
| Award (this year) | $578,588 |
| NIH project number | 7R01NS106879-06 |
| Project ID | NIH-10753623 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals who have experienced a stroke and are seeking new therapeutic options to aid their recovery.
✕Less likely to help
Patients who have not had a stroke or those with conditions unrelated to stroke recovery may not benefit from this research.
What this research studies
This research focuses on developing small molecule activators that enhance the function of neurolysin, a peptidase involved in the brain's self-repair mechanisms after a stroke. By understanding how neurolysin works, the researchers aim to create drug-like compounds that can mimic or boost the brain's natural protective responses. The goal is to advance these compounds through the drug discovery process, potentially leading to new therapies that improve recovery outcomes for stroke patients.
Why it matters
Potential benefit: If successful, this research could lead to innovative treatments that significantly enhance recovery and brain health after a stroke.
How similar studies have gone: Previous studies have shown promise in targeting neurolysin for stroke therapy, indicating that this approach could be a meaningful advancement in treatment.
Where this research is happening
-
Oakland University
Rochester, United States Active
Researchers
- Principal investigator: Karamyan, Vardan T. — Oakland University
- Study coordinator: Karamyan, Vardan T.
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.