Creating new drugs to block an enzyme linked to Alzheimer's disease
Development of neutral sphingomyelinase 2 (nSMase2) inhibitors for the treatment of Alzheimer's disease
This study is looking at a new way to help people with Alzheimer's by creating a special treatment that blocks an enzyme linked to the disease, which could lead to better options for slowing down its progression.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Johns Hopkins University NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project ID | NIH-10936519 on NIH RePORTER |
What this research studies
This research focuses on developing inhibitors for neutral sphingomyelinase 2 (nSMase2), an enzyme that plays a role in the progression of Alzheimer's disease. By blocking this enzyme, the study aims to reduce the production of harmful substances that contribute to the disease's pathology. The research involves optimizing a prototype inhibitor and testing its effectiveness through various scientific methods. Patients may benefit from new treatment options that could slow the progression of Alzheimer's disease.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals aged 65 and older who are experiencing symptoms of Alzheimer's disease.
Not a fit: Patients with early-stage Alzheimer's or those under 65 years of age may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that significantly slow the progression of Alzheimer's disease.
How similar studies have performed: Previous research has shown promise in targeting similar pathways in Alzheimer's disease, suggesting potential for success in this approach.
Where this research is happening
Baltimore, United States
- Johns Hopkins University — Baltimore, United States (Active)
Researchers
- Principal investigator: Tsukamoto, Takashi — Johns Hopkins University
- Study coordinator: Tsukamoto, Takashi
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.