Creating new drugs that help destroy specific proteins in cells
Official title: Development of Ubiquitin-Independent Degraders
Funded at University of Florida · NIH-10914808 · Data updated 2026-11-12
This study is exploring new ways to create special compounds that can help your body get rid of harmful proteins that can cause health problems, making it easier to keep your cells healthy and potentially leading to better treatments for diseases linked to these proteins.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Florida NIH-funded |
| Lab location | 1 site (Gainesville, United States) |
| Project start | September 1, 2023 |
| Project end | August 31, 2028 |
| Funding year | 2024 |
| Award (this year) | $826,413 |
| NIH project number | 5R01CA290247-02 |
| Project ID | NIH-10914808 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research would include individuals with conditions linked to protein misfolding or accumulation, such as certain cancers or neurodegenerative diseases.
✕Less likely to help
Patients with conditions not related to protein degradation or those whose diseases do not involve the targeted proteins may not benefit from this research.
What this research studies
This research focuses on developing innovative chemical compounds known as degraders that can effectively target and eliminate specific proteins within cells. By recruiting these proteins directly to the proteasome, the research aims to simplify the process of protein destruction, which is crucial for maintaining cellular health. The approach involves enhancing protein-protein interactions to ensure that the targeted proteins are efficiently degraded without the need for prior modification. This could lead to more effective treatments for diseases caused by dysfunctional proteins.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that effectively eliminate harmful proteins associated with various diseases.
How similar studies have gone: Other research has shown promise in developing similar degraders, indicating a potential for success in this novel approach.
Where this research is happening
-
University of Florida
Gainesville, United States Active
Researchers
- Principal investigator: Kodadek, Thomas J. — University of Florida
- Study coordinator: Kodadek, Thomas J.
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.