Creating new drugs by modifying natural compounds
Official title: Synthesis and Modification of Natural Products through Inert Bond Cleavage Reactions
Funded at Vanderbilt University · NIH-11022185 · Data updated 2026-11-12
This study is exploring new ways to change natural substances that help create medicines, aiming to make treatments for conditions like HIV and cancer more effective and with fewer side effects, so patients can have better options for their health.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Vanderbilt University NIH-funded |
| Lab location | 1 site (Nashville, UNITED STATES) |
| Project start | January 1, 2025 |
| Project end | December 31, 2029 |
| Funding year | 2025 |
| Award (this year) | $395,881 |
| NIH project number | 1R35GM156918-01 |
| Project ID | NIH-11022185 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals affected by HIV, cancers, or other conditions that could benefit from new therapeutic agents derived from modified natural products.
✕Less likely to help
Patients who do not have conditions related to HIV or cancer may not receive direct benefits from this research.
What this research studies
This research focuses on developing innovative methods to modify natural products, which are often used as templates for new medications. By employing advanced techniques to alter the core structure of these compounds, the project aims to enhance their effectiveness and reduce side effects. The approach involves breaking and reforming chemical bonds to create new molecular configurations that could lead to better therapeutic candidates. Patients may benefit from improved treatments for conditions like HIV and various cancers as a result of these advancements.
Why it matters
Potential benefit: If successful, this research could lead to the development of more effective and safer medications for patients.
How similar studies have gone: Other research has shown promise in modifying natural products for therapeutic use, indicating that this approach has potential for success.
Where this research is happening
-
Vanderbilt University
Nashville, United States Active
Researchers
- Principal investigator: Schuppe, Alexander W. — Vanderbilt University
- Study coordinator: Schuppe, Alexander W.
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.