Creating new drug candidates using unique chemical structures
Official title: Biocatalytic Synthesis of N-N and C-N Heterobiaryl Atropisomers
Funded at University of Michigan at Ann Arbor · NIH-11070727 · Data updated 2026-11-12
This study is working on creating new types of medicines that could work better and have fewer side effects by using special chemical structures, and it aims to help patients get safer and more effective treatments.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Michigan at Ann Arbor NIH-funded |
| Lab location | 1 site (Ann Arbor, United States) |
| Project start | December 1, 2024 |
| Project end | November 30, 2027 |
| Funding year | 2025 |
| Award (this year) | $73,408 |
| NIH project number | 1F32GM157984-01 |
| Project ID | NIH-11070727 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals who may benefit from new anti-cancer or anti-bacterial drugs.
✕Less likely to help
Patients who are not affected by conditions that require new drug therapies may not receive any benefit from this research.
What this research studies
This research focuses on developing new small-molecule drug candidates by introducing a specific type of chemical structure known as atropisomers, which can enhance the effectiveness and safety of medications. The approach involves using natural enzymes to create these structures through a direct coupling process, which is more efficient than traditional methods. By employing bioinformatics tools, the research aims to identify and optimize these chemical reactions to produce potent pharmaceutical agents. Patients may benefit from improved drugs that have better absorption and fewer side effects.
Why it matters
Potential benefit: If successful, this research could lead to the development of more effective and safer medications for various conditions.
How similar studies have gone: Other research has shown promise in using similar enzymatic approaches to create effective drug candidates, indicating a potential for success in this area.
Where this research is happening
-
University of Michigan at Ann Arbor
Ann Arbor, United States Active
Researchers
- Principal investigator: Williams, Wendy L — University of Michigan at Ann Arbor
- Study coordinator: Williams, Wendy L
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.