Creating new compounds to enhance DNA interactions for disease treatment
Official title: Development of flavone- and flavonoid-based DNA triplex specific binding ligands as antigene enhancers
Funded at University of the Pacific-Stockton · NIH-10799314 · Data updated 2026-11-12
This study is exploring new ways to create special molecules that can help target a unique form of DNA called triplex DNA, which could lead to better treatments for certain diseases.
Quick facts
| Grant type | R15 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of the Pacific-Stockton NIH-funded |
| Lab location | 1 site (Stockton, United States) |
| Project start | September 21, 2022 |
| Project end | August 31, 2025 |
| Funding year | 2023 |
| Award (this year) | $48,516 |
| NIH project number | 3R15GM148914-01S1 |
| Project ID | NIH-10799314 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with genetic disorders or diseases that could benefit from targeted DNA therapies.
✕Less likely to help
Patients with conditions unrelated to DNA interactions or those not amenable to antigene strategies may not benefit from this research.
What this research studies
This research focuses on developing specific binding ligands that interact with triplex DNA, which is a unique structure of DNA that can be targeted for therapeutic purposes. By using an advanced gel imaging system, researchers will study how these ligands can enhance the formation of triplex DNA, potentially leading to new strategies for treating diseases. The project involves constructing plasmid DNA and using various gel electrophoresis techniques to visualize and analyze the effectiveness of these ligands in preventing DNA digestion by enzymes. This innovative approach aims to improve our understanding of DNA interactions and their implications for disease treatment.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies that enhance the effectiveness of treatments for various diseases by targeting DNA more precisely.
How similar studies have gone: While the approach of using flavonoid-based ligands is innovative, similar strategies targeting DNA interactions have shown promise in other research, suggesting potential for success.
Where this research is happening
-
University of the Pacific-Stockton
Stockton, United States Active
Researchers
- Principal investigator: Xue, Liang — University of the Pacific-Stockton
- Study coordinator: Xue, Liang
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.