Creating new complex molecules for potential drug development
Official title: Rapid Synthesis of Topologically Complex Molecules with Tungsten Dearomatization Agents
Funded at University of Virginia · NIH-11038259 · Data updated 2026-11-12
This study is exploring new ways to create complex molecules that could help in making better medicines, using a special technique to change simple compounds into more useful ones for drug discovery.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Virginia NIH-funded |
| Lab location | 1 site (Charlottesville, United States) |
| Project start | December 15, 2023 |
| Project end | November 30, 2028 |
| Funding year | 2025 |
| Award (this year) | $79,310 |
| NIH project number | 3R35GM152065-02S1 |
| Project ID | NIH-11038259 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with conditions that could benefit from new pharmaceutical agents developed from these complex molecules.
✕Less likely to help
Patients who are not seeking new treatment options or those with conditions that are not addressed by the types of drugs being developed may not benefit from this research.
What this research studies
This research focuses on developing innovative methods to synthesize complex molecules that could lead to new pharmaceutical agents. By using tungsten dearomatization agents, the team aims to transform simple aromatic compounds like benzene into more complex structures that can be explored for their medicinal properties. The approach involves adding various chemical fragments to these newly formed structures, potentially expanding the range of compounds available for drug discovery. This work could significantly enhance the diversity of molecules that medicinal chemists can work with in developing new treatments.
Why it matters
Potential benefit: If successful, this research could lead to the discovery of new drugs that are more effective in treating various diseases.
How similar studies have gone: Previous research has shown success in developing new synthetic methods for complex molecules, indicating a promising avenue for drug discovery.
Where this research is happening
-
University of Virginia
Charlottesville, United States Active
Researchers
- Principal investigator: Harman, Walter Dean — University of Virginia
- Study coordinator: Harman, Walter Dean
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.