Creating new complex molecules for drug development
Official title: Rapid Synthesis of Topologically Complex Molecules with Tungsten Dearomatization Agents
Funded at University of Virginia · NIH-11000797 · Data updated 2026-11-12
This study is looking at new ways to create complex molecules that could help make better medicines, using a special technique to change simple compounds into more useful ones, which might lead to new treatments for different health conditions.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Virginia NIH-funded |
| Lab location | 1 site (Charlottesville, United States) |
| Project start | December 15, 2023 |
| Project end | November 30, 2028 |
| Funding year | 2025 |
| Award (this year) | $343,690 |
| NIH project number | 5R35GM152065-02 |
| Project ID | NIH-11000797 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for participation or benefit from this research would be individuals with conditions that could be treated by new drug therapies developed from these complex molecules.
✕Less likely to help
Patients with conditions that are not addressed by the types of drugs being developed from these new molecules may not receive any benefit.
What this research studies
This research focuses on developing innovative methods to synthesize complex molecules that can be used in pharmaceuticals. By utilizing tungsten dearomatization agents, the team aims to transform simple aromatic compounds like benzene into more complex structures that can lead to new drug candidates. The approach involves exploring various chemical reactions to create diverse molecular shapes, which could enhance the discovery of effective medications. Patients may benefit from this research as it could lead to the development of new treatments for various diseases.
Why it matters
Potential benefit: If successful, this research could lead to the creation of new pharmaceutical agents that improve treatment options for patients.
How similar studies have gone: Previous research has shown success in developing new synthetic methods for drug discovery, indicating that this approach has potential for meaningful advancements.
Where this research is happening
-
University of Virginia
Charlottesville, United States Active
Researchers
- Principal investigator: Harman, Walter Dean — University of Virginia
- Study coordinator: Harman, Walter Dean
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.