Creating new combination therapies for a type of kidney cancer
Developing novel polytherapies for Non-Clear Cell Renal Cell Carcinoma
['FUNDING_R01'] · OREGON HEALTH & SCIENCE UNIVERSITY · NIH-11047661
This study is exploring new treatment options for people with Non-Clear Cell Renal Cell Carcinoma, a tough type of kidney cancer, by testing a mix of two drugs that could help stop the cancer from growing and surviving.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | OREGON HEALTH & SCIENCE UNIVERSITY (nih funded) |
| Locations | 1 site (PORTLAND, UNITED STATES) |
| Trial ID | NIH-11047661 on ClinicalTrials.gov |
What this research studies
This research focuses on developing innovative combination therapies for Non-Clear Cell Renal Cell Carcinoma (NCCRCC), a type of kidney cancer that currently lacks approved treatments. The approach involves using a combination of JAK and AKT inhibitors to target critical signaling pathways that promote tumor growth. By analyzing how these treatments affect cancer cells and patient tumors, the researchers aim to understand and overcome the mechanisms that allow cancer cells to survive despite therapy. This could lead to more effective treatment options for patients suffering from this aggressive cancer.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients diagnosed with Non-Clear Cell Renal Cell Carcinoma who have limited treatment options.
Not a fit: Patients with other types of kidney cancer or those who do not have Non-Clear Cell Renal Cell Carcinoma may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could provide new, effective treatment options for patients with Non-Clear Cell Renal Cell Carcinoma, potentially improving survival rates.
How similar studies have performed: While this approach is innovative, previous studies have shown promise in targeting similar pathways in other cancers, suggesting potential for success.
Where this research is happening
PORTLAND, UNITED STATES
- OREGON HEALTH & SCIENCE UNIVERSITY — PORTLAND, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: THOMAS, GEORGE VICTOR — OREGON HEALTH & SCIENCE UNIVERSITY
- Study coordinator: THOMAS, GEORGE VICTOR
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: anti-cancer therapy