Creating new chemical reactions to make medicines
Phosphine-Catalyzed Annulations and their Applications
This project aims to develop advanced chemical methods that could help create new medications, potentially for conditions like Alzheimer's disease.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California Los Angeles NIH-funded |
| Lab location | 1 site (Los Angeles, United States) |
| Project ID | NIH-11123310 on NIH RePORTER |
What this research studies
Our goal is to invent new catalysts and chemical reactions that make it easier to build complex drug molecules. We are designing special phosphine oxides that are highly reactive and can be used to speed up important chemical processes. This work focuses on improving the efficiency and environmental impact of creating new pharmaceuticals. By developing these innovative chemical tools, we hope to enable the synthesis of medicines that are currently difficult or costly to produce.
Who could benefit from this research
Good fit: This foundational chemistry work does not directly involve patient participation.
Not a fit: Patients seeking immediate treatment or direct clinical involvement would not find a direct benefit from this basic science project.
Why it matters
Potential benefit: If successful, this work could lead to more efficient and environmentally friendly ways to produce new drugs, potentially including treatments for Alzheimer's disease.
How similar studies have performed: Our previous work has shown that these new phosphine oxides exhibit superior reactivity compared to existing methods, demonstrating great promise for future applications.
Where this research is happening
Los Angeles, United States
- University of California Los Angeles — Los Angeles, United States (Active)
Researchers
- Principal investigator: Kwon, Ohyun — University of California Los Angeles
- Study coordinator: Kwon, Ohyun
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.