Creating new chemical compounds to study bacterial behavior and develop treatments.
Official title: Access to Strained Rings and Heterocycles: Applications in the Synthesis of Bacterial Metabolites and Chemical Building Blocks
Funded at California Institute of Technology · NIH-11033895 · Data updated 2026-11-12
This study is all about creating special chemicals that can help us understand how certain bacteria, like the one that affects cystic fibrosis patients, form protective layers called biofilms, with the hope of finding new ways to treat these infections.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | California Institute of Technology NIH-funded |
| Lab location | 1 site (Pasadena, United States) |
| Project start | September 12, 2024 |
| Project end | August 31, 2026 |
| Funding year | 2024 |
| Award (this year) | $125,000 |
| NIH project number | 1K99GM157554-01 |
| Project ID | NIH-11033895 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with cystic fibrosis who are affected by Pseudomonas aeruginosa infections.
✕Less likely to help
Patients without cystic fibrosis or those not affected by Pseudomonas aeruginosa may not benefit from this research.
What this research studies
This research focuses on synthesizing unique chemical structures known as strained rings and heterocycles, which are important for understanding bacterial metabolites. The project aims to create specific metabolites that influence biofilm formation in bacteria like Pseudomonas aeruginosa, particularly affecting cystic fibrosis patients. By developing these compounds, researchers hope to evaluate their biological functions and potentially create new treatments that target bacterial virulence. The approach involves innovative chemical reactions to construct these complex molecules efficiently.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for cystic fibrosis by targeting harmful bacterial behaviors.
How similar studies have gone: Other research has shown promise in developing chemical compounds to target bacterial infections, indicating potential success for this approach.
Where this research is happening
-
California Institute of Technology
Pasadena, United States Active
Researchers
- Principal investigator: Dorn, Stanna — California Institute of Technology
- Study coordinator: Dorn, Stanna
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.