Creating new cellular behaviors using genetic sensors and circuits
Official title: Development of Genetic Sensors and Circuits for Creating Novel Cellular Behaviors
Funded at University of North Texas · NIH-10916266 · Data updated 2026-11-12
This study is working on creating smart genetic tools that can react to different chemical signals in the body, which could help improve tests and treatments for various health issues, making life easier for patients.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of North Texas NIH-funded |
| Lab location | 1 site (Denton, United States) |
| Project start | September 15, 2021 |
| Project end | August 31, 2026 |
| Funding year | 2024 |
| Award (this year) | $360,055 |
| NIH project number | 5R35GM142421-04 |
| Project ID | NIH-10916266 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for participation or benefit from this research would include individuals with conditions that could be addressed through advanced cellular therapies or diagnostics.
✕Less likely to help
Patients with conditions unrelated to cellular signaling or those who do not require innovative therapeutic approaches may not receive benefits from this research.
What this research studies
This research focuses on developing advanced genetic circuits that can respond to multiple chemical signals, which is a significant challenge in synthetic biology. By engineering genetic sensors and utilizing a module swapping strategy, the team aims to create novel cellular functions that can be applied in biomedical contexts. Patients may benefit from these advancements as they could lead to improved diagnostics and treatments for various health conditions. The research involves a systematic approach to enhance the performance of transcriptional regulators as biosensors, which could revolutionize how we understand and manipulate cellular behavior.
Why it matters
Potential benefit: If successful, this research could lead to innovative therapies and diagnostics that utilize engineered cells to respond to specific biological signals.
How similar studies have gone: Other research in synthetic biology has shown promise in developing genetic circuits, indicating that this approach has potential for success.
Where this research is happening
-
University of North Texas
Denton, United States Active
Researchers
- Principal investigator: Chan, Tsz Yan Clement — University of North Texas
- Study coordinator: Chan, Tsz Yan Clement
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.