Creating new catalysts to improve antibiotics
Official title: Development of Metallopeptides for Site-Selective Transformations of the Antibiotic Thiostrepton
Funded at Yale University · NIH-11066728 · Data updated 2026-11-12
This study is looking at new ways to make antibiotics work better against tough bacteria by using special tiny proteins, which could help improve treatments for patients dealing with infections that don't respond to regular antibiotics.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Yale University NIH-funded |
| Lab location | 1 site (New Haven, United States) |
| Project start | January 1, 2025 |
| Project end | December 31, 2027 |
| Funding year | 2025 |
| Award (this year) | $75,052 |
| NIH project number | 1F32GM154398-01A1 |
| Project ID | NIH-11066728 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are patients suffering from infections caused by antibiotic-resistant bacteria.
✕Less likely to help
Patients with infections that are not caused by antibiotic-resistant bacteria may not benefit from this research.
What this research studies
This research focuses on developing innovative synthetic peptide catalysts that can enhance the effectiveness of antibiotics by enabling precise chemical transformations. By mimicking the selectivity of natural enzymes, these catalysts aim to address the growing issue of antibiotic resistance. The project will explore how these peptide-based catalysts can be used in complex reactions involving antibiotics, potentially leading to more effective treatments. Patients may benefit from improved antibiotic therapies that are more effective against resistant bacterial strains.
Why it matters
Potential benefit: If successful, this research could lead to more effective antibiotics that can overcome drug resistance.
How similar studies have gone: Other research has shown promise in using synthetic catalysts for chemical transformations, but this specific approach is relatively novel.
Where this research is happening
-
Yale University
New Haven, United States Active
Researchers
- Principal investigator: Peterson, Paul Oliver — Yale University
- Study coordinator: Peterson, Paul Oliver
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.