Creating new cancer models from diverse patient tumors
United for Health Equity - Living PDX Program (U4HELPP)
['FUNDING_OTHER'] · VIRGINIA COMMONWEALTH UNIVERSITY · NIH-11064403
This study is working to create special models from tumors of patients with advanced cancers like breast and pancreatic cancer, especially focusing on including people from diverse backgrounds, to help find better treatments that work for everyone.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | VIRGINIA COMMONWEALTH UNIVERSITY (nih funded) |
| Locations | 1 site (RICHMOND, UNITED STATES) |
| Trial ID | NIH-11064403 on ClinicalTrials.gov |
What this research studies
The United for Health Equity - Living PDX Program (U4HELPP) aims to develop over 500 patient-derived xenograft (PDX) models from tumors of patients with breast, pancreatic, colon, liver, lung, and other advanced peritoneal cancers. This initiative focuses on including more than 60% of patients from underrepresented populations, ensuring diverse genetic representation. Tumors will be extracted and processed to create PDXs, which will then undergo genomic characterization to understand how ancestry influences cancer genetics and treatment responses. The resulting models will be used to identify more effective therapies for pancreatic and breast cancers.
Who could benefit from this research
Good fit: Ideal candidates for participation are patients diagnosed with breast, pancreatic, colon, liver, lung, or advanced peritoneal cancers, especially those from underrepresented racial and ethnic backgrounds.
Not a fit: Patients with cancers not included in the study, or those who do not belong to underrepresented populations, may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective and personalized cancer treatments for patients, particularly those from underrepresented populations.
How similar studies have performed: Similar research approaches have shown promise in developing patient-derived models, but this specific initiative is particularly focused on enhancing diversity in cancer research.
Where this research is happening
RICHMOND, UNITED STATES
- VIRGINIA COMMONWEALTH UNIVERSITY — RICHMOND, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: TREVINO, JOSE G. — VIRGINIA COMMONWEALTH UNIVERSITY
- Study coordinator: TREVINO, JOSE G.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Breast Cancer, Cancer Center, Cancer Model, CancerModel