Creating new biomolecules to improve protein function in human cells
Leveraging Next-Generation Directed Evolution Platforms and Chemical Control of Proteostasis to Deliver Robust Biotechnologies and Illuminate Roles of Chaperone Networks in Protein Evolution
This study is exploring new ways to create and improve biomolecules that can work better in human cells, which could help develop better treatments for various health conditions.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Massachusetts Institute of Technology NIH-funded |
| Lab location | 1 site (Cambridge, United States) |
| Project ID | NIH-11064239 on NIH RePORTER |
What this research studies
This research focuses on advancing the process of directed evolution, which accelerates natural evolution in a lab setting to develop new biomolecules. The team has created a unique platform that allows for the generation of large libraries of mutant biomolecules that can be tested directly in human cells, overcoming challenges faced when transferring these molecules from simpler organisms. Additionally, the research investigates the proteostasis network, which is crucial for proper protein folding and function, using innovative chemical tools to enhance this process. By integrating these approaches, the research aims to evolve biomolecules that can better function in complex cellular environments.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with conditions related to protein misfolding or dysfunction, such as certain cancers.
Not a fit: Patients with conditions unrelated to protein function or those who do not have a genetic component to their disease may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to the development of more effective treatments for various diseases, including cancers, by improving protein function.
How similar studies have performed: Previous research has shown promise in directed evolution techniques, but this specific approach integrating proteostasis modulation is relatively novel.
Where this research is happening
Cambridge, United States
- Massachusetts Institute of Technology — Cambridge, United States (Active)
Researchers
- Principal investigator: Shoulders, Matthew Donald — Massachusetts Institute of Technology
- Study coordinator: Shoulders, Matthew Donald
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.