Creating new bacterial viruses to fight antibiotic resistance
AN ADAPTIVE FRAMEWORK TO SYNTHESIZE AND RECONFIGURE BACTERIAL VIRUSES (PHAGES) TO COUNTER ANTIBIOTIC RESISTANCE
['FUNDING_CAREER'] · CALIFORNIA INSTITUTE OF TECHNOLOGY · NIH-11033792
This study is exploring a new way to create and adjust viruses that can target and kill antibiotic-resistant bacteria, which could offer patients a helpful alternative to traditional antibiotics for treating tough infections.
Quick facts
| Phase | ['FUNDING_CAREER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | CALIFORNIA INSTITUTE OF TECHNOLOGY (nih funded) |
| Locations | 1 site (PASADENA, UNITED STATES) |
| Trial ID | NIH-11033792 on ClinicalTrials.gov |
What this research studies
This research focuses on developing a new method to create and modify bacterial viruses, known as phages, to effectively treat infections caused by antibiotic-resistant bacteria. The approach involves decompressing phage genomes to allow for more flexible engineering and rapid synthesis of these viruses using a cell-free system. By doing so, the researchers aim to enhance the scalability and accessibility of phage therapy, making it a viable treatment option for various drug-resistant infections. Patients may benefit from this innovative therapy as it could provide effective alternatives to traditional antibiotics.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals suffering from infections caused by antibiotic-resistant bacteria.
Not a fit: Patients with infections that are not caused by antibiotic-resistant bacteria may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for infections that are currently difficult to manage due to antibiotic resistance.
How similar studies have performed: Other research has shown promise in using phage therapy for antibiotic-resistant infections, indicating that this approach has potential for success.
Where this research is happening
PASADENA, UNITED STATES
- CALIFORNIA INSTITUTE OF TECHNOLOGY — PASADENA, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: ZHANG, YAN — CALIFORNIA INSTITUTE OF TECHNOLOGY
- Study coordinator: ZHANG, YAN
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.