Creating new antimicrobial agents to fight infections
Protein engineering for the development of novel antimicrobial agents
['FUNDING_CAREER'] · MASSACHUSETTS GENERAL HOSPITAL · NIH-10853082
This study is working on creating new antibiotics to help fight tough infections caused by bacteria that don't respond to regular treatments, using special proteins that can kill these bacteria and boost the immune system, with the goal of making better medicines for patients.
Quick facts
| Phase | ['FUNDING_CAREER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | MASSACHUSETTS GENERAL HOSPITAL (nih funded) |
| Locations | 1 site (BOSTON, UNITED STATES) |
| Trial ID | NIH-10853082 on ClinicalTrials.gov |
What this research studies
This research focuses on developing novel antibiotics to combat antimicrobial resistance, which poses a significant threat to effective infection treatment. The approach involves engineering antimicrobial peptides (AMPs), which are small proteins that can kill bacteria and modulate immune responses. The research aims to understand how these AMPs work against gram-negative bacteria and to create new therapeutic versions of a specific AMP called LL-37. By leveraging advanced chemistry techniques, the project seeks to pave the way for new treatments that could significantly improve patient outcomes.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients suffering from infections caused by antibiotic-resistant bacteria.
Not a fit: Patients with infections that are not caused by antibiotic-resistant bacteria may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to the development of new antibiotics that effectively treat infections resistant to current medications.
How similar studies have performed: Previous research has shown promise in developing antimicrobial peptides as effective treatments, indicating a potential for success in this novel approach.
Where this research is happening
BOSTON, UNITED STATES
- MASSACHUSETTS GENERAL HOSPITAL — BOSTON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: ALBIN, JOHN S. — MASSACHUSETTS GENERAL HOSPITAL
- Study coordinator: ALBIN, JOHN S.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Cancers