Creating new antibiotics and anticancer drugs from natural products
Official title: Modular synthesis of antibiotic and anticancer classes of natural products
Funded at Scripps Research Institute, the · NIH-11235034 · Data updated 2026-11-12
This study is working on making new and better antibiotics and cancer drugs from natural sources that could help people but have been tricky to use, by simplifying their structures to make them more effective.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Scripps Research Institute, the NIH-funded |
| Lab location | 1 site (La Jolla, United States) |
| Project start | August 1, 2023 |
| Project end | July 31, 2028 |
| Funding year | 2024 |
| Award (this year) | $390,650 |
| NIH project number | 7R35GM148184-03 |
| Project ID | NIH-11235034 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research would include patients with infections caused by antibiotic-resistant bacteria or those with specific types of cancer.
✕Less likely to help
Patients who do not have infections or cancers that are targeted by the new drugs being developed may not benefit from this research.
What this research studies
This research focuses on developing new synthetic methods to create antibiotics and anticancer drugs derived from natural products that have shown promise but face challenges in their therapeutic use. By simplifying the chemical structure of these compounds, the researchers aim to enhance their effectiveness and overcome existing limitations. The project involves using advanced techniques like X-ray and cryo-electron microscopy to inform the design of these new compounds. The ultimate goal is to produce potent drug candidates that can be optimized for treating infections and cancer.
Why it matters
Potential benefit: If successful, this research could lead to the development of more effective antibiotics and anticancer therapies, potentially improving treatment outcomes for patients.
How similar studies have gone: Previous research has shown success in developing novel antibiotics from natural products, indicating that this approach has potential for significant breakthroughs.
Where this research is happening
-
Scripps Research Institute, the
La Jolla, United States Active
Researchers
- Principal investigator: Seiple, Ian Bass — Scripps Research Institute, the
- Study coordinator: Seiple, Ian Bass
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.