Creating new 3D-shaped medicines for COVID-19
Developing three-dimensional antisense oligonucleotide drugs against COVID-19
This work focuses on making new types of medicines called 3D-ASOs that specifically target the COVID-19 virus to stop it from replicating.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California Los Angeles NIH-funded |
| Lab location | 1 site (Los Angeles, United States) |
| Project ID | NIH-11125807 on NIH RePORTER |
What this research studies
The COVID-19 virus has a large genetic blueprint made of RNA, which is essential for its survival and spread. Our approach uses special molecules called antisense oligonucleotides (ASOs) that are designed to stick to this viral RNA. Unlike traditional ASOs, our '3D-ASOs' are crafted to recognize not just the sequence but also the unique folded shapes of the virus's RNA. This precise fit helps the 3D-ASOs bind more strongly and specifically to the virus, aiming to block its ability to multiply.
Who could benefit from this research
Good fit: This foundational research is currently in the drug development phase and is not yet recruiting patients for direct participation.
Not a fit: Patients not infected with SARS-CoV-2, the virus causing COVID-19, would not directly benefit from this specific antiviral treatment.
Why it matters
Potential benefit: If successful, this research could lead to highly effective new treatments for COVID-19 that specifically target the virus with fewer side effects.
How similar studies have performed: Antisense oligonucleotide drugs have been approved for other viral infections, suggesting a proven concept, but this 3D-ASO design approach is novel for COVID-19.
Where this research is happening
Los Angeles, United States
- University of California Los Angeles — Los Angeles, United States (Active)
Researchers
- Principal investigator: Guo, Feng — University of California Los Angeles
- Study coordinator: Guo, Feng
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.