Creating MRI tests to detect Alzheimer's disease
Developing Protein-based MRI Biomarkers for Alzheimer's Disease
This study is exploring a new way to use MRI scans to spot Alzheimer's disease and similar conditions in people, using a special technique that helps show changes in the brain, making it easier to diagnose the disease early and manage it better.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Johns Hopkins University NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project ID | NIH-10893952 on NIH RePORTER |
What this research studies
This research focuses on developing new MRI biomarkers to identify Alzheimer's disease and related conditions. By utilizing a novel protein-based MRI technique called amide proton transfer imaging, the study aims to visualize changes in the brain associated with Alzheimer's in living patients. This approach builds on previous successes in detecting brain tumors and aims to provide a non-invasive method for diagnosing Alzheimer's at various stages, including mild cognitive impairment and preclinical phases. The research seeks to enhance the accuracy of Alzheimer's diagnosis and improve patient management.
Who could benefit from this research
Good fit: Ideal candidates for this research include older adults experiencing cognitive decline or those diagnosed with mild cognitive impairment or Alzheimer's disease.
Not a fit: Patients with cognitive decline due to causes other than Alzheimer's disease or those who are not elderly may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to earlier and more accurate diagnosis of Alzheimer's disease, allowing for timely interventions and better patient outcomes.
How similar studies have performed: Previous studies have shown success in using similar MRI techniques for detecting brain tumors, indicating potential for this approach in Alzheimer's diagnosis.
Where this research is happening
Baltimore, United States
- Johns Hopkins University — Baltimore, United States (Active)
Researchers
- Principal investigator: Zhou, Jinyuan — Johns Hopkins University
- Study coordinator: Zhou, Jinyuan
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.