Creating MRI agents to track kidney disease in children with acidemias
Developing MRI contrast agents to detect progression in renal disease as a consequence of acidema
This study is testing new MRI tools to help doctors better check kidney health in kids with rare metabolic disorders that can affect their kidneys, making it easier to keep them healthy.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Hugo W. Moser Res Inst Kennedy Krieger NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project ID | NIH-10551303 on NIH RePORTER |
What this research studies
This research focuses on developing new MRI contrast agents that can help monitor kidney function in children suffering from organic acidemias, a group of rare metabolic disorders. These disorders can lead to chronic kidney disease, which is difficult to assess using traditional methods like blood tests. The study will utilize innovative chemical compounds that create MRI contrast through a technique called Chemical Exchange Saturation Transfer (CEST), allowing for detailed imaging of kidney health and pH levels. By providing a more reliable way to monitor kidney function, this research aims to improve the management of these patients' health.
Who could benefit from this research
Good fit: Ideal candidates for this research are children aged 0-21 diagnosed with organic acidemias, particularly those at risk of chronic kidney disease.
Not a fit: Patients who do not have organic acidemias or chronic kidney disease may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to better monitoring and management of kidney health in children with organic acidemias, potentially improving their overall health outcomes.
How similar studies have performed: While the use of MRI contrast agents is established, the specific application of CEST for monitoring kidney function in this patient population is novel and has not been extensively tested.
Where this research is happening
Baltimore, United States
- Hugo W. Moser Res Inst Kennedy Krieger — Baltimore, United States (Active)
Researchers
- Principal investigator: Mcmahon, Michael T — Hugo W. Moser Res Inst Kennedy Krieger
- Study coordinator: Mcmahon, Michael T
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.