Creating mouse models to study human genes related to Alzheimer's Disease
Full human gene replacement mouse models of Alzheimer's Disease
This study is creating special mice that have human genes linked to Alzheimer's Disease to help researchers understand how the disease works and to test new treatments that could help people with Alzheimer's.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Minnesota NIH-funded |
| Lab location | 1 site (Minneapolis, United States) |
| Project ID | NIH-10525102 on NIH RePORTER |
What this research studies
This research focuses on developing advanced mouse models that incorporate full human genes associated with Alzheimer's Disease (AD). By replacing mouse genes with their human counterparts, the study aims to replicate the genetic and pathological features of AD in these models. The research will evaluate various human genes known to influence AD risk and pathology, ensuring that the models accurately reflect the disease's characteristics. These models will be used to better understand the mechanisms of AD and to test potential treatments.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with a genetic predisposition to Alzheimer's Disease or those interested in the genetic factors influencing the condition.
Not a fit: Patients without a family history or genetic risk factors for Alzheimer's Disease may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and treatment options for Alzheimer's Disease.
How similar studies have performed: Previous research has shown promise in using gene replacement techniques in animal models, indicating potential for success in this novel approach.
Where this research is happening
Minneapolis, United States
- University of Minnesota — Minneapolis, United States (Active)
Researchers
- Principal investigator: Koob, Michael D — University of Minnesota
- Study coordinator: Koob, Michael D
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.